Abstract | PURPOSE: MATERIALS AND METHODS:
Androgen independent PC-3 prostate cancer cells and PC-3 transfectant clones over expressing the apoptosis suppressor bcl-2 were used as an in vitro model. Cells were treated with pharmacologically relevant doses of 1 of the 3 alpha1-adrenoceptor antagonists and the effect on cell viability/cell adhesion on various substrates was examined. Analysis of expression of key attachment factors, such as vascular endothelial growth factor ( VEGF) and hypoxia inducible factor-alpha, was performed. RESULTS: CONCLUSIONS:
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Authors | Kasapr Keledjian, Natasha Kyprianou |
Journal | The Journal of urology
(J Urol)
Vol. 169
Issue 3
Pg. 1150-6
(Mar 2003)
ISSN: 0022-5347 [Print] United States |
PMID | 12576871
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic alpha-1 Receptor Antagonists
- Adrenergic alpha-Antagonists
- Endothelial Growth Factors
- HIF1A protein, human
- Hypoxia-Inducible Factor 1, alpha Subunit
- Intercellular Signaling Peptides and Proteins
- Lymphokines
- Proto-Oncogene Proteins c-bcl-2
- Sulfonamides
- Transcription Factors
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Terazosin
- Tamsulosin
- Doxazosin
- Prazosin
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Topics |
- Adrenergic alpha-1 Receptor Antagonists
- Adrenergic alpha-Antagonists
(pharmacology)
- Anoikis
(drug effects)
- Cell Adhesion
(drug effects)
- Cell Survival
(drug effects)
- Doxazosin
(pharmacology)
- Endothelial Growth Factors
(metabolism)
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit
- Intercellular Signaling Peptides and Proteins
(metabolism)
- Lymphokines
(metabolism)
- Male
- Neoplasm Invasiveness
- Prazosin
(analogs & derivatives, pharmacology)
- Prostatic Neoplasms
(metabolism, physiopathology)
- Proto-Oncogene Proteins c-bcl-2
(pharmacology)
- Sulfonamides
(pharmacology)
- Tamsulosin
- Transcription Factors
(metabolism)
- Tumor Cells, Cultured
(drug effects, physiology)
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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