Suppression of antibody production by TNF-related apoptosis-inducing ligand (TRAIL).

Abstract	TNF-related apoptosis-inducing ligand (TRAIL), a type II membrane protein belonging to the TNF family, induces apoptotic cell death in various types of tumor cells. However, little is known about its pathological and physiological functions in the immune system. In this study, we showed that administration of neutralizing anti-TRAIL mAb markedly increased serum auto-Ab levels, particularly of IgG1 subclass, in autoimmune-prone C3H/HeJ gld/gld mice without affecting lymphocytosis and lymphocytes populations. In an experimental system where TNP-specific Ab production was induced by immunization with TNP-modified syngeneic B lymphoma cells, expression of TRAIL on these cells significantly reduced TNP-specific Ab production, especially of IgG1 subclass, without affecting T cell priming. These results suggest a new role for TRAIL in the suppression of Ab production.
Authors	Nobuhiko Kayagaki, Noriko Yamaguchi, Masaaki Abe, Sachiko Hirose, Toshikazu Shirai, Ko Okumura, Hideo Yagita
Journal	Cellular immunology (Cell Immunol) Vol. 219 Issue 2 Pg. 82-91 (Oct 2002) ISSN: 0008-8749 [Print] Netherlands
PMID	12576026 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antibodies Antibodies, Monoclonal Apoptosis Regulatory Proteins Autoantibodies CD4 Antigens CD8 Antigens Fas Ligand Protein Fasl protein, mouse Immunoglobulin G Membrane Glycoproteins Picrates TNF-Related Apoptosis-Inducing Ligand Tnfsf10 protein, mouse Tumor Necrosis Factor-alpha picric acid
Topics	Animals Antibodies (analysis) Antibodies, Monoclonal (administration & dosage) Apoptosis Apoptosis Regulatory Proteins Autoantibodies (blood) Autoimmune Diseases (blood, immunology) CD4 Antigens (analysis) CD8 Antigens (analysis) Fas Ligand Protein Female Immunoglobulin G (blood) Injections, Intraperitoneal Lymphoma, B-Cell (immunology) Membrane Glycoproteins (blood, genetics, immunology, physiology) Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Mutant Strains Mutation Picrates T-Lymphocytes (immunology) TNF-Related Apoptosis-Inducing Ligand Transfection Tumor Necrosis Factor-alpha (immunology, physiology)

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