[Study on preparation and tissue distribution of SEA liposomes].

Abstract

OBJECTIVE:

To make a study on the preparation and tissue distribution of staphylococcal enterotoxin A (SEA) liposomes and to provide scientific basis for the therapy of liver cancer by using SEA liposomes.

METHODS:

SEA liposomes were prepared by reverse-phase evaporation; the diameter and entrapment efficiency (EC) of SEA liposomes were determined. 125I labeled SEA solution and 125I-SEA liposomes were administrated intravenously to mice, respectively. The radioactivity of the organs was determined by gamma-counter.

RESULTS:

The mean diameter and EC of SEA liposomes were 505 +/- 34 nm and 44.1% +/- 4.8%, respectively. SEA liposomes were found mainly distributed in the liver and spleen. SEA liposomes had a higher blood clearance, compared with SEA solution; SEA solution had high-radio-activity in plasma and kidney; there was statistical significance between the two groups (P < 0.05).

CONCLUSION:

The preparation method of SEA liposomes is simple and repeatable. SEA liposomes possess liver-targeting properties and may provide a new application foreground for the treatment of liver cancer.

• Authors: Zhiyu Li, Sheng He, Hua Xue, Min Su, Xian Wang
• Journal: Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao (Hua Xi Yi Ke Da Xue Xue Bao) Vol. 33 Issue 2 Pg. 299-301, 304 (Apr 2002) ISSN: 0257-7712 [Print] China
• PMID: 12575216 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Carriers
• Enterotoxins
• Liposomes
• enterotoxin A, Staphylococcal

Topics

• Animals
• Drug Carriers
• Drug Delivery Systems (methods)
• Enterotoxins (administration & dosage, pharmacokinetics)
• Female
• Liposomes
• Liver (metabolism)
• Male
• Mice
• Random Allocation
• Tissue Distribution