Abstract |
Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an X-linked genetic component. Recent studies have identified an X chromosomal susceptibility region (Xq24-q28) in two typical migraine pedigrees. This region harbours a potential candidate gene for the disorder, the serotonin receptor 2C (5-HT(2C)) gene. This study involved a linkage and association approach to investigate two single nucleotide variants in the 5-HT(2C) gene. In addition, exonic coding regions of the 5-HT(2C) gene were also sequenced for mutations in X-linked migraine pedigrees. Results of this study did not detect any linkage or association, and no disease causing mutations were identified. Hence, results for this study do not support a significant role of the 5-HT(2C) gene in migraine predisposition.
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Authors | Matthew P Johnson, Rod A Lea, Robert P Curtain, John C MacMillan, Lyn R Griffiths |
Journal | American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
(Am J Med Genet B Neuropsychiatr Genet)
Vol. 117B
Issue 1
Pg. 86-9
(Feb 2003)
ISSN: 1552-4841 [Print] United States |
PMID | 12555241
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2003 Wiley-Liss, Inc. |
Chemical References |
- Receptor, Serotonin, 5-HT2C
- Receptors, Serotonin
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Topics |
- Case-Control Studies
- Chromosomes, Human, X
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Migraine Disorders
(genetics)
- Polymorphism, Single Nucleotide
- Receptor, Serotonin, 5-HT2C
- Receptors, Serotonin
(genetics)
- Sex Factors
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