An investigation of the 5-HT2C receptor gene as a migraine candidate gene.

Abstract

Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an X-linked genetic component. Recent studies have identified an X chromosomal susceptibility region (Xq24-q28) in two typical migraine pedigrees. This region harbours a potential candidate gene for the disorder, the serotonin receptor 2C (5-HT(2C)) gene. This study involved a linkage and association approach to investigate two single nucleotide variants in the 5-HT(2C) gene. In addition, exonic coding regions of the 5-HT(2C) gene were also sequenced for mutations in X-linked migraine pedigrees. Results of this study did not detect any linkage or association, and no disease causing mutations were identified. Hence, results for this study do not support a significant role of the 5-HT(2C) gene in migraine predisposition.

• Authors: Matthew P Johnson, Rod A Lea, Robert P Curtain, John C MacMillan, Lyn R Griffiths
• Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet) Vol. 117B Issue 1 Pg. 86-9 (Feb 2003) ISSN: 1552-4841 [Print] United States
• PMID: 12555241 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2003 Wiley-Liss, Inc.

Chemical References

• Receptor, Serotonin, 5-HT2C
• Receptors, Serotonin

Topics

• Case-Control Studies
• Chromosomes, Human, X
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Migraine Disorders (genetics)
• Polymorphism, Single Nucleotide
• Receptor, Serotonin, 5-HT2C
• Receptors, Serotonin (genetics)
• Sex Factors