Abstract | AIMS: METHODS: To elucidate the ethanol effects on platelets in murine AIDS, we studied four groups: control, murine AIDS, ethanol, and ethanol plus murine AIDS. Platelet CD62p as a platelet activation marker and CD61(+) microparticles as platelet microparticles (PMPs) were measured by flow cytometry. RESULTS: Platelets were significantly activated in mice with murine AIDS and chronic ethanol consumption. Increased platelet CD62p expression and increased PMPs were most pronounced in advanced stages of murine AIDS. Chronic ethanol consumption persistently enhanced platelet activation and PMP formation. CONCLUSIONS: Elevated platelet CD62p and PMPs may represent a pro-thrombotic status that have important pathological consequences.
|
Authors | Yinhong Chen, Grace Davis-Gorman, Ronald R Watson, Paul F McDonagh |
Journal | Alcohol and alcoholism (Oxford, Oxfordshire)
(Alcohol Alcohol)
2003 Jan-Feb
Vol. 38
Issue 1
Pg. 25-30
ISSN: 0735-0414 [Print] England |
PMID | 12554603
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
|
Topics |
- Alcohol Drinking
(adverse effects, blood)
- Alcoholism
(blood)
- Animals
- Blood Platelets
(drug effects)
- Female
- Flow Cytometry
- Inclusion Bodies
(drug effects)
- Mice
- Mice, Inbred C57BL
- Murine Acquired Immunodeficiency Syndrome
(blood)
- P-Selectin
(blood)
- Platelet Activation
(drug effects)
- Platelet Count
|