HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Exposure to oral uranyl nitrate delays tooth eruption and development.

Abstract
The risk of oral exposure to uranium potentially involves the population at large. Tooth eruption and development are ongoing processes that begin during fetal development and continue until the age of 18 y. Since one of the mechanisms involved in tooth eruption is bone formation and it is well documented that uranium inhibits bone formation, the aim of the present work was to study the effect of oral administration of uranyl nitrate (UN) on tooth eruption and development. Wistar rats aged 1 and 7 d were orally administered a single dose of 90 mg kg(-1) body weight of uranyl nitrate. Two age matched groups received an equal volume of saline and served as controls. The animals were killed at 7 and 14 d of age, respectively. Mandibles were resected and processed to obtain bucco-lingual sections oriented at the level of the mesial root of the first mandibular molar, and histomorphometric studies were performed. Results showed that an acute high dose of uranyl nitrate delays both tooth eruption and development, probably due to its effect on target cells.
AuthorsM M Pujadas Bigi, L Lemlich, P M Mandalunis, A M Ubios
JournalHealth physics (Health Phys) Vol. 84 Issue 2 Pg. 163-9 (Feb 2003) ISSN: 0017-9078 [Print] United States
PMID12553645 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Uranyl Nitrate
Topics
  • Animals
  • Animals, Newborn
  • Bone Development (radiation effects)
  • Bone Resorption (etiology)
  • Environmental Exposure (adverse effects)
  • Odontogenesis (radiation effects)
  • Rats
  • Rats, Wistar
  • Tooth (growth & development, radiation effects)
  • Tooth Eruption (radiation effects)
  • Uranyl Nitrate (toxicity)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: