Topical therapy with tretinoin and ammonium lactate for acanthosis nigricans associated with obesity.

Abstract

Acanthosis nigricans (AN) is a cutaneous marker of various underlying systemic conditions. To date, no satisfactory topical therapy for this cutaneous disorder has been described. The following is a report of the successful use of a combination of 12% ammonium lactate cream and 0.05% tretinoin cream to treat AN associated with obesity.

• Authors: Steven H Blobstein
• Journal: Cutis (Cutis) Vol. 71 Issue 1 Pg. 33-4 (Jan 2003) ISSN: 0011-4162 [Print] United States
• PMID: 12553628 (Publication Type: Case Reports, Journal Article)

Chemical References

• Keratolytic Agents
• Quaternary Ammonium Compounds
• Lactic Acid
• Tretinoin

Topics

• Acanthosis Nigricans (drug therapy, etiology, pathology)
• Administration, Topical
• Adolescent
• Drug Therapy, Combination
• Humans
• Keratolytic Agents (administration & dosage, therapeutic use)
• Lactic Acid (administration & dosage, therapeutic use)
• Male
• Obesity (complications)
• Quaternary Ammonium Compounds (administration & dosage, therapeutic use)
• Tretinoin (administration & dosage, therapeutic use)