Human immunodeficiency virus type 1 RNA polymerase chain reaction reasonably excludes infection in exposed infants.

Abstract

A nucleic acid sequence-based amplification (NASBA) assay that detects HIV RNA may be helpful in excluding perinatal HIV infection. We reviewed the records of 190 infants born to HIV-infected mothers. The sensitivity and specificity of the NASBA assay were 100% when measured at two time periods in the first 9 months of life. The HIV RNA NASBA assay should be considered a valid diagnostic test in this population.

• Authors: Jorge Luján-Zilbermann, Wally Bitar, Katherine Knapp, Patricia Flynn
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 22 Issue 1 Pg. 97-9 (Jan 2003) ISSN: 0891-3668 [Print] United States
• PMID: 12553306 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• RNA, Viral

Topics

• Child
• HIV Infections (diagnosis, transmission)
• HIV-1 (genetics, isolation & purification)
• Humans
• Infant
• Infectious Disease Transmission, Vertical
• Polymerase Chain Reaction
• RNA, Viral (analysis)
• Self-Sustained Sequence Replication (methods)
• Sensitivity and Specificity