Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: We evaluated the clinical parameters, C-peptide levels, and islet cell-specific autoantibodies in 54 LADA, 57 adult-onset type 1 diabetic, and 190 type 2 diabetic patients. Islet cell autoantibodies were also compared between subgroups of newly diagnosed patients with LADA and those with newly diagnosed adult-onset and childhood-onset type 1 diabetes. The genetic study was performed in subjects with LADA and those with adult-onset type 1 diabetes in comparison with a control population. RESULTS: There were no differences in the clinical parameters between LADA and adult-onset type 1 diabetes. Patients with LADA had lower BMI (P < 0.0001), waist-to-hip ratio (0.0029), total cholesterol (P = 0.001), and triglycerides (P = 0.001); higher HDL cholesterol levels (P < 0.0001); and lower prevalence of hypertension (P = 0.0028) compared with patients with type 2 diabetes. C-peptide levels were similar at onset (P = 0.403) but decreased less rapidly in LADA than in adult-onset type 1 diabetes (P = 0.0253). Single- autoantibody positivity was more often seen in LADA than in type 1 diabetes (P = 0.0001). The prevalence of predisposing HLA-DQB1*0302, -DR4, -DR3, and -DR3/DR4 genotypes and the DR4-DQB1*0302 haplotype were increased in both LADA and adult-onset type 1 diabetic subjects compared with the control population. There were no differences in the frequencies of these risk alleles and haplotypes between the two patient groups. CONCLUSIONS: Subjects with LADA had clinical characteristics similar to those with adult-onset type 1 diabetes with rapid progression. C-peptide levels did not differ at onset but decreased less rapidly in LADA. Patients with LADA rather had single islet cell-specific autoantibody positivity. The prevalence of HLA-DQB1*0302, -DR4, -DR3, and -DR3/DR4 risk alleles and the DR4-DQB1*0302 high-risk haplotype did not differ in the two forms of autoimmune diabetes.
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Authors | Nóra Hosszúfalusi, Agnes Vatay, Katalin Rajczy, Zoltán Prohászka, Eva Pozsonyi, Laura Horváth, Andrea Grosz, László Gerõ, László Madácsy, László Romics, István Karádi, George Füst, Pál Pánczél |
Journal | Diabetes care
(Diabetes Care)
Vol. 26
Issue 2
Pg. 452-7
(Feb 2003)
ISSN: 0149-5992 [Print] United States |
PMID | 12547879
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Autoantibodies
- C-Peptide
- islet cell antibody
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Topics |
- Adult
- Aged
- Alleles
- Autoantibodies
(analysis)
- C-Peptide
(blood)
- Diabetes Mellitus, Type 1
(blood, genetics, immunology, physiopathology)
- Disease Progression
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Male
- Middle Aged
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