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Tonin in rat heart with experimental hypertrophy.

Abstract
The present study was undertaken to determine tonin expression and activity in rat heart presenting isoproterenol-induced hypertrophy. Renin, angiotensin-converting enzyme (ACE), and angiotensinogen (AG) expression were also determined. Wistar rats were treated with isoproterenol for 7 days (5 mg x kg(-1) x day(-1) sc). For untreated animals, the levels of tonin-specific activity in the atrium were 2.6- and 5.5-fold higher than those of the left and right ventricle, respectively. After treatment, the levels of tonin-specific activity increased twofold in the atrium but did not change in the ventricles. Renin expression was not detectable in these structures, and ACE expression levels did not change with treatment. AG expression was detected in the left ventricle at very low levels compared with the atrium and increased significantly only in the hypertrophied atrium (1.8-fold). Tonin mRNA was not detected in the ventricle but was found at low levels in the atrium, which increased after isoproterenol treatment. Our results permit us to conclude that tonin may play a role in the process of heart hypertrophy in the rat.
AuthorsJulio Cesar Borges, José Antônio Silva Jr, Maria Aparecida Gomes, Eliane Sa Lopes Lomez, Katia Moraes Leite, Ronaldo Carvalho Araujo, Michael Bader, João Bosco Pesquero, Jorge Luiz Pesquero
JournalAmerican journal of physiology. Heart and circulatory physiology (Am J Physiol Heart Circ Physiol) Vol. 284 Issue 6 Pg. H2263-8 (Jun 2003) ISSN: 0363-6135 [Print] United States
PMID12543632 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adrenergic beta-Agonists
  • RNA Probes
  • Angiotensin II
  • Atrial Natriuretic Factor
  • tonin
  • Tissue Kallikreins
  • Isoproterenol
Topics
  • Adrenergic beta-Agonists
  • Angiotensin II (biosynthesis)
  • Animals
  • Atrial Natriuretic Factor (biosynthesis)
  • Cardiomegaly (chemically induced, metabolism)
  • Disease Progression
  • Gene Expression Regulation
  • Isoproterenol
  • Male
  • Myocardium (metabolism)
  • Organ Size (drug effects)
  • RNA Probes
  • Rats
  • Rats, Wistar
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tissue Kallikreins (biosynthesis, metabolism)

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