[An experimental study on effects of pingyangmycin on vessels].

The aim of this study was to investigate the mechanism of Pingyangmycin sclerotherapy for cavernous hemangiomas.
Totally 9 rabbits (one as the control) were selected to be injected with Pingyangmycin and sodium morrhuate into the auricularis posterior vein, and then these veins were examined histologically 2, 7, 14 and 21 days after injection respectively.
After injection, Pingyangmycin nonspecifically made the endothelia and veins defective, and induced proliferation of endothelial cells and smooth muscle cells after 7 days. Further, the veins became sclerostenosis 21 days after injection. On the other hand, sodium morrhuate caused thrombosis quickly and the vascular cavity disappeared. Finally, the thrombus became fibrogenesis. The local skin could be observed swollen and necrosis.
Pingyangmycin is a better sclerosant for the therapy of cavernous hemangioma.
AuthorsQ Gao, C Wang, Y Wen, L Li, J Zhang, Z He, Z Yang
JournalHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology (Hua Xi Kou Qiang Yi Xue Za Zhi) Vol. 19 Issue 3 Pg. 184-7 (Jun 2001) ISSN: 1000-1182 [Print] China
PMID12539410 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibiotics, Antineoplastic
  • Bleomycin
  • zhengguangmycin
  • Animals
  • Antibiotics, Antineoplastic (therapeutic use)
  • Bleomycin (analogs & derivatives, therapeutic use)
  • Ear, External (blood supply)
  • Endothelium, Vascular (drug effects, pathology)
  • Female
  • Hemangioma, Cavernous (drug therapy)
  • Injections, Intralesional
  • Male
  • Rabbits
  • Sclerotherapy
  • Veins (drug effects, pathology)

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