Regional odontodysplasia: expression of matrix metalloproteinases and their natural inhibitors.

Abstract

Regional odontodysplasia is a localized disorder of tissues of dental origin that results in a ghost-like appearance of the affected teeth. We present a case with a study of gingival tissue around the follicle. The results show evidence of the role of the matrix metalloproteinases and their natural inhibitors by resident cells in this pathosis. An imbalance in the amounts of matrix metalloproteinases and their natural inhibitors is associated with the pathologic breakdown of the collagen.

• Authors: Frédéric Courson, Fadi Bdeoui, Marc Danan, Michel Degrange, Bruno Gogly
• Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 95 Issue 1 Pg. 60-6 (Jan 2003) ISSN: 1079-2104 [Print] United States
• PMID: 12539028 (Publication Type: Case Reports, Journal Article)

Chemical References

• Tissue Inhibitor of Metalloproteinases
• Collagen
• Matrix Metalloproteinases

Topics

• Blotting, Western
• Case-Control Studies
• Child
• Collagen (metabolism)
• Connective Tissue (enzymology)
• Dental Sac (enzymology)
• Gingiva (enzymology)
• Humans
• Image Processing, Computer-Assisted
• Immunoblotting
• Incisor (ultrastructure)
• Male
• Matrix Metalloproteinases (biosynthesis)
• Microscopy, Electron, Scanning
• Odontodysplasia (enzymology)
• Tissue Inhibitor of Metalloproteinases (biosynthesis)