Radium in Wisconsin drinking water: an analysis of osteosarcoma risk.

Abstract

Epidemiological studies of radium dial painters have found an association between exposure to high-dose radium and bone cancers. However, only limited data exist on the relationship between low doses of radium, as are found in some drinking water sources, and osteosarcoma. The authors conducted a population-based case-control study to examine the association between exposure to radium in drinking water and the occurrence of osteosarcoma. Estimates of radium exposure and covariates used were based on subjects' residential ZIP codes. The median radium level was not significantly associated with osteosarcoma (odds ratio = .98; 95% confidence interval = .93, 1.04; p = .56). The authors found no evidence that radium, at current levels in Wisconsin drinking water, resulted in excess cases of osteosarcoma.

• Authors: Clare E Guse, Anne M Marbella, Varghese George, Peter M Layde
• Journal: Archives of environmental health (Arch Environ Health) 2002 Jul-Aug Vol. 57 Issue 4 Pg. 294-303 ISSN: 0003-9896 [Print] United States
• PMID: 12530595 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Radium

Topics

• Adolescent
• Adult
• Aged
• Bone Neoplasms (epidemiology, etiology)
• Case-Control Studies
• Child
• Child, Preschool
• Female
• Humans
• Infant
• Infant, Newborn
• Male
• Middle Aged
• Odds Ratio
• Osteosarcoma (epidemiology, etiology)
• Radium (adverse effects, analysis)
• Registries (statistics & numerical data)
• Risk Assessment
• Water Supply
• Wisconsin (epidemiology)