[Methionine synthase and neural tube defects].

Abstract

It has been indicated lately that higher plasma homocysteine is one of the risk factors in neural tube defects(NTDs) and vascular disease. Methionine synthase is a key enzyme in homocysteine metabolism. The defects of methionine synthase activity could result in hyperhomocysteinemia and methionine auxotrophy. The gene mutations of methionine synthase with the epidemiological studies of NTDs are reviewed in this paper. It is considered that the gene mutations of methionine synthase can not make a relation to NTDs and hyperhomocysteine, but methionine synthase reductase may be a clue for the study on NTDs in the future.

• Authors: T Zhao, H Zhu, Y Li
• Journal: Wei sheng yan jiu = Journal of hygiene research (Wei Sheng Yan Jiu) Vol. 29 Issue 6 Pg. 397-400 (Nov 2000) ISSN: 1000-8020 [Print] China
• PMID: 12520968 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase

Topics

• 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (genetics)
• China (epidemiology)
• Humans
• Neural Tube Defects (enzymology, epidemiology, genetics)
• Point Mutation