Abstract | BACKGROUND & OBJECTIVE: METHODS: This is a multi-center phase II clinical trial. The previously chemotherapy treated patients with NSCLC were administrated nedaplatin alone. Nedaplatin was given at 100 mg/m2, i.v., repeated every 3 weeks. The chemonaive patients with NSCLC were randomized to two groups. The combination trial group was given with nedaplatin + vindesine regimen, and the combination control group with cisplatin + vindesine. RESULTS: Of 138 patients, 16 were in the nedaplatin single drug group; 60 were in the combination trial group; and 62 were in the combination control group. All of the 16 cases in the single drug group, which were treated with platinum previously, achieved 12.5% of response rate. And the combination trial group and control group had a very similar response rate, which were 26.7% versus 25.8%, respectively. The incidence rates of neutropenia and anemia were similar in the two groups. But the incidence rate of thrombocytopenia was higher in the trial group than that in the control group. Nedaplatin has a possibility to result in mild nausea/ vomiting. CONCLUSION:
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Authors | Rui-hua Xu, Zhong-zhen Guan, Wen-qi Jiang, He Huang, Xiao-hua Hu, Wei-min Xie, Xing-gen Li, Ya-li Liu, Liang-xi Pan, Ai-di Dai, Wu Zhuang, Chun Zhang, Zhi-yong Ma, Jian-hua Wang |
Journal | Ai zheng = Aizheng = Chinese journal of cancer
(Ai Zheng)
Vol. 21
Issue 12
Pg. 1354-8
(Dec 2002)
China |
PMID | 12520747
(Publication Type: Clinical Trial, Clinical Trial, Phase II, English Abstract, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antineoplastic Agents
- Organoplatinum Compounds
- nedaplatin
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Topics |
- Adult
- Aged
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Carcinoma, Non-Small-Cell Lung
(drug therapy)
- Female
- Humans
- Lung Neoplasms
(drug therapy)
- Male
- Middle Aged
- Nausea
(etiology)
- Organoplatinum Compounds
(adverse effects, therapeutic use)
- Treatment Outcome
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