Abstract | OBJECTIVE: METHODS: Eighty collagenase-induced ICH rats were used. At 12 h, 24 h, 2 d, 4 d, 7 d, cytochrome c oxidase(CO) activity was measured with histochemistry combined with gray scale scanning. Pyramidal cell(PC) counting was also employed following Nissl's staining. RESULTS: The CO activities in NYA-treated group were less than those in model control group, and the neuronal loss was less in NYA-treated group than that in model control group. CONCLUSIONS: The neuronal protective mechanism of NYA following ICH may be related with its maintaining activity of cytochrome c oxidase, which contributes to improving cellular aerobic metabolism and increasing energy supply for cells.
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Authors | T Tang, Q H Liang, X Q Li |
Journal | Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University
(Hunan Yi Ke Da Xue Xue Bao)
Vol. 25
Issue 6
Pg. 542-4
(Dec 28 2000)
ISSN: 1000-5625 [Print] China |
PMID | 12516399
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Combinations
- Drugs, Chinese Herbal
- Neuroprotective Agents
- Electron Transport Complex IV
- Collagenases
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Topics |
- Animals
- Cerebral Hemorrhage
(chemically induced, enzymology)
- Collagenases
- Drug Combinations
- Drugs, Chinese Herbal
(pharmacology)
- Electron Transport Complex IV
(metabolism)
- Hippocampus
(enzymology)
- Male
- Neuroprotective Agents
(pharmacology)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
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