[Effects of Nao-Yi-An granule on activity of cytochrome c oxidase in hippocampus of experimental intracerebral hemorrhagic rats].

To explore the neuronal protective effects of a traditional Chinese medicine complex Nao-Yi-An granule(NYA) on experimental intracerebral hemorrhage(ICH) in rats.
Eighty collagenase-induced ICH rats were used. At 12 h, 24 h, 2 d, 4 d, 7 d, cytochrome c oxidase(CO) activity was measured with histochemistry combined with gray scale scanning. Pyramidal cell(PC) counting was also employed following Nissl's staining.
The CO activities in NYA-treated group were less than those in model control group, and the neuronal loss was less in NYA-treated group than that in model control group.
The neuronal protective mechanism of NYA following ICH may be related with its maintaining activity of cytochrome c oxidase, which contributes to improving cellular aerobic metabolism and increasing energy supply for cells.
AuthorsT Tang, Q H Liang, X Q Li
JournalHunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University (Hunan Yi Ke Da Xue Xue Bao) Vol. 25 Issue 6 Pg. 542-4 (Dec 28 2000) ISSN: 1000-5625 [Print] China
PMID12516399 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drug Combinations
  • Drugs, Chinese Herbal
  • Neuroprotective Agents
  • Electron Transport Complex IV
  • Collagenases
  • Animals
  • Cerebral Hemorrhage (chemically induced, enzymology)
  • Collagenases
  • Drug Combinations
  • Drugs, Chinese Herbal (pharmacology)
  • Electron Transport Complex IV (metabolism)
  • Hippocampus (enzymology)
  • Male
  • Neuroprotective Agents (pharmacology)
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley

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