Abstract |
This study was conducted to determine the prevalence and clinical association of anticardiolipin antibodies (ACA) in serum of patients with systemic lupus erythematosus (SLE). ACA ( IgG, IgA, IgM) was measured by enzyme-linked immunosorbent assay (ELISA) in the serum sample of 87 patients of SLE. The prevalence rates of ACAIgG, ACAIgA and ACAIgM were 62.1%, 52.9% and 35.6% respectively. The titers of ACAIgG and ACAIgM were positively correlated with the disease activity (r = 0.2763, P = 0.044; r = 0.3294, P = 0.018); ACAIgG, ACAIgA and ACAIgM were negatively correlated with complement C3 (r = -0.4737, P = 0.000; r = -0.2990, P = 0.017; r = -0.2758, P = 0.029); and ACAIgG was negatively correlated with complement C4 (r = -0.4079, P = 0.005). The titers of ACAIgA in patients with thrombosis was higher than that in patients without thrombosis. The patients with central nervous system involvement (CNS-SLE) had significantly higher ACAIgG and ACAIgM titers, compared with those without CNS-SLE. The results indicate there is a correlation between ACA titers and disease activity. In patients with thrombosis, the titer of ACAIgA is higher, and in patients with CNS-SLE, the titers of ACAIgG and ACAIgM are higher.
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Authors | G Liu, Z Wang, L Wang, Q Xie, R Zhang, C Zuo, M Lin |
Journal | Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao
(Hua Xi Yi Ke Da Xue Xue Bao)
Vol. 31
Issue 2
Pg. 223-5
(Jun 2000)
ISSN: 0257-7712 [Print] China |
PMID | 12515143
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antibodies, Anticardiolipin
- Immunoglobulins
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Topics |
- Adolescent
- Adult
- Antibodies, Anticardiolipin
(blood)
- Child
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Immunoglobulins
(blood)
- Lupus Erythematosus, Systemic
(complications, immunology)
- Male
- Middle Aged
- Vasculitis, Central Nervous System
(etiology)
- Venous Thrombosis
(etiology)
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