Effect of CCR5-delta32 heterozygosity on the risk of perinatal HIV-1 infection: a meta-analysis.

Abstract

Several studies have investigated whether heterozygosity for a 32-basepair deletion in the CC chemokine receptor 5 gene (CCR5-Delta32 ) affects susceptibility to perinatal HIV-1 infection, but results have been inconclusive. We performed a meta-analysis of published data from 11 studies of HIV-1 perinatally exposed children who were genotyped for the CCR5-Delta32 polymorphism. The crude overall HIV-1 infection rates, by simple data pooling, were 20% (one of five) amongCCR5-Delta32 homozygote children, 39% (131 of 335) among CCR5-Delta32 heterozygote children, and 40% (1408 of 3526) among wild-type CCR5 homozygote children. Compared with wild-type homozygotes, the random effects risk ratio for heterozygotes was 1.04 (95% confidence interval [CI], 0.92-1.17) among all children (N = 3861) and 1.03 (95% CI, 0.90-1.17) among those of European descent (n = 2890). Results were similar when adjusted for the available data on the CCR2-641 polymorphism (n = 1542). The meta-analysis clarifies that perinatal infection is not significantly altered by heterozygosity for CCR5-Delta32 in the child.

• Authors: Despina G Contopoulos-Ioannidis, Thomas R O'Brien, James J Goedert, Phillip S Rosenberg, John P A Ioannidis
• Journal: Journal of acquired immune deficiency syndromes (1999) (J Acquir Immune Defic Syndr) Vol. 32 Issue 1 Pg. 70-6 (Jan 01 2003) ISSN: 1525-4135 [Print] United States
• PMID: 12514416 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Receptors, CCR5

Topics

• Europe (ethnology)
• Female
• HIV Infections (ethnology, genetics, transmission)
• HIV-1 (physiology)
• Heterozygote
• Homozygote
• Humans
• Infant, Newborn
• Infectious Disease Transmission, Vertical
• Male
• Polymorphism, Genetic (genetics)
• Pregnancy
• Racial Groups (genetics)
• Receptors, CCR5 (genetics)
• Risk Factors