Abstract |
Several studies have investigated whether heterozygosity for a 32-basepair deletion in the CC chemokine receptor 5 gene (CCR5-Delta32 ) affects susceptibility to perinatal HIV-1 infection, but results have been inconclusive. We performed a meta-analysis of published data from 11 studies of HIV-1 perinatally exposed children who were genotyped for the CCR5-Delta32 polymorphism. The crude overall HIV-1 infection rates, by simple data pooling, were 20% (one of five) amongCCR5-Delta32 homozygote children, 39% (131 of 335) among CCR5-Delta32 heterozygote children, and 40% (1408 of 3526) among wild-type CCR5 homozygote children. Compared with wild-type homozygotes, the random effects risk ratio for heterozygotes was 1.04 (95% confidence interval [CI], 0.92-1.17) among all children (N = 3861) and 1.03 (95% CI, 0.90-1.17) among those of European descent (n = 2890). Results were similar when adjusted for the available data on the CCR2-641 polymorphism (n = 1542). The meta-analysis clarifies that perinatal infection is not significantly altered by heterozygosity for CCR5-Delta32 in the child.
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Authors | Despina G Contopoulos-Ioannidis, Thomas R O'Brien, James J Goedert, Phillip S Rosenberg, John P A Ioannidis |
Journal | Journal of acquired immune deficiency syndromes (1999)
(J Acquir Immune Defic Syndr)
Vol. 32
Issue 1
Pg. 70-6
(Jan 01 2003)
ISSN: 1525-4135 [Print] United States |
PMID | 12514416
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
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Topics |
- Europe
(ethnology)
- Female
- HIV Infections
(ethnology, genetics, transmission)
- HIV-1
(physiology)
- Heterozygote
- Homozygote
- Humans
- Infant, Newborn
- Infectious Disease Transmission, Vertical
- Male
- Polymorphism, Genetic
(genetics)
- Pregnancy
- Racial Groups
(genetics)
- Receptors, CCR5
(genetics)
- Risk Factors
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