A paradoxical ocular effect of brimonidine.

Abstract

PURPOSE:

We report an unusual paradoxical effect of brimonidine.

DESIGN:

Observational case report.

METHODS:

A 70-year-old woman with bilateral normal tension glaucoma was treated with topical brimonidine and followed in an outpatient setting. The main outcome measured was intraocular pressure (IOP) in mm Hg.

RESULTS:

Brimonidine was observed to cause IOP elevation, confirmed on rechallenge, scoring 8 (strong probability) on an adverse drug reaction probability score.

CONCLUSION:

Under certain circumstances topical brimonidine can cause paradoxical raised IOP necessitating vigilance in follow-up of patients on topical brimonidine.

• Authors: Bushra Mushtaq, Jagadish Sardar, Tim D Matthews
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 135 Issue 1 Pg. 102-3 (Jan 2003) ISSN: 0002-9394 [Print] United States
• PMID: 12504711 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenergic alpha-Agonists
• Quinoxalines
• Brimonidine Tartrate

Topics

• Adrenergic alpha-Agonists (adverse effects)
• Aged
• Brimonidine Tartrate
• Female
• Glaucoma, Open-Angle (drug therapy)
• Humans
• Intraocular Pressure (drug effects)
• Ocular Hypertension (chemically induced)
• Quinoxalines (adverse effects)