Monoamine oxidase: A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorder.
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| Abstract |
Monoamine oxidase A (MAOA) and tryptophan hydroxylase (TPH) are the staple enzymes in the metabolism of serotonin (5-HT). The genetic polymorphisms of these two enzymes might individually alter the production, release, reuptake or degradation of 5-HT during the treatment of selective serotonin reuptake inhibitors (SSRIs), leading to the individual differences in the antidepressant effects of SSRIs. The authors investigated whether a functional polymorphism in the MAOA gene promoter (MAOA-VNTR) and a TPH gene polymorphism in intron 7 (TPH-A218C) were associated with the antidepressant response to fluvoxamine in 66 Japanese patients with major depressive disorder during a 6-week study with a specific dosage plan. Fifty-four patients completed the study. The present study fails to demonstrate that the genetic polymorphisms of MAOA-VNTR and TPH-A218C affect the antidepressant effect of fluvoxamine in Japanese patients with major depressive disorder.
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| Authors | Keizo Yoshida, Shingo Naito, Hitoshi Takahashi, Kazuhiro Sato, Kenichi Ito, Mitsuhiro Kamata, Hisashi Higuchi, Tetsuo Shimizu, Kunihiko Itoh, Kazuyuki Inoue, Takehiko Tezuka, Toshio Suzuki, Tadashi Ohkubo, Kazunobu Sugawara, Koichi Otani |
| Journal | Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry) Vol. 26 Issue 7-8 Pg. 1279-83 (Dec 2002) ISSN: 0278-5846 [Print] England |
| PMID | 12502014 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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