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Endocytosis and sorting of glycosphingolipids in sphingolipid storage disease.

Abstract
Recent studies on the endocytic itinerary of glycosphingolipids (GSLs) in sphingolipid storage disease (SLSD) fibroblasts have yielded new insights into the mechanisms underlying the endocytosis and intracellular sorting of lipids in normal and disease cells. Here we highlight new data on clathrin-independent endocytosis of GSLs, the involvement of sphingolipid-cholesterol interactions in perturbation of endocytic trafficking, and potential roles for rab proteins in regulation of GSL transport in SLSDs.
AuthorsDavid L Marks, Richard E Pagano
JournalTrends in cell biology (Trends Cell Biol) Vol. 12 Issue 12 Pg. 605-13 (Dec 2002) ISSN: 0962-8924 [Print] England
PMID12495850 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References
  • Glycosphingolipids
  • Cholesterol
  • rab GTP-Binding Proteins
Topics
  • Animals
  • Biological Transport
  • Cholesterol (metabolism)
  • Endocytosis
  • Glycosphingolipids (metabolism)
  • Humans
  • Models, Biological
  • Sphingolipidoses (metabolism, pathology, therapy)
  • rab GTP-Binding Proteins (metabolism)

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