Relationship between DNA mismatch repair genes expression, Ku-genes expression and ploidy-related parameters in the progression of pigmented lesions of the skin.

Abstract	Defects of DNA repair systems in cutaneous tumours are related to DNA mismatch repair genes (MLH1, MSH2, PMS1, PMS2) and Ku70/80 genes involved in double- strand repair. In this study we investigated the statistical relationship between these systems and DNA-ploidy-related parameters in 19 naevus cell naevi, 23 lentigos maligna, 76 primary melanomas and 31 melanoma metastases, applying the correlation coefficient according to Spearman. In naevi significant correlations were found between Ku70/80 gene expression and some ploidy-related parameters. In lentigos, additionally, some significant correlations between the expression of DNA mismatch repair genes were found. Similar results were demonstrated for primary melanomas. In metastases no one significant correlation between DNA mismatch repair genes and Ku-genes was present. We postulate that DNA mismatch repair genes and Ku70/80 genes are functionally independent and that some of them are able to influence ploidy-related parameters.
Authors	Monika Korabiowska, Michael Tscherny, Jerzy Stachura, Ilka Ruschenburg, Carlos Cordon-Cardo, Ulrich Brinck
Journal	In vivo (Athens, Greece) (In Vivo) 2002 Sep-Oct Vol. 16 Issue 5 Pg. 317-21 ISSN: 0258-851X [Print] Greece
PMID	12494870 (Publication Type: Journal Article)
Chemical References	Adaptor Proteins, Signal Transducing Antigens, Nuclear Carrier Proteins DNA, Neoplasm DNA-Binding Proteins MLH1 protein, human Neoplasm Proteins Nuclear Proteins PMS1 protein, human Proto-Oncogene Proteins Adenosine Triphosphatases PMS2 protein, human MSH2 protein, human Mismatch Repair Endonuclease PMS2 MutL Protein Homolog 1 MutL Proteins MutS Homolog 2 Protein DNA Helicases XRCC5 protein, human Xrcc6 protein, human Ku Autoantigen DNA Repair Enzymes
Topics	Adaptor Proteins, Signal Transducing Adenosine Triphosphatases (genetics, metabolism) Adult Aged Aged, 80 and over Antigens, Nuclear (genetics, metabolism) Base Pair Mismatch Carrier Proteins (genetics, metabolism) Cell Count DNA Helicases DNA Repair DNA Repair Enzymes DNA, Neoplasm (analysis, genetics) DNA-Binding Proteins (genetics, metabolism) Female Humans Hutchinson's Melanotic Freckle (genetics, pathology) Image Cytometry Immunohistochemistry Ku Autoantigen Lymphatic Metastasis (genetics, pathology) Male Melanoma (genetics, metabolism, secondary) Middle Aged Mismatch Repair Endonuclease PMS2 MutL Protein Homolog 1 MutL Proteins MutS Homolog 2 Protein Neoplasm Proteins (genetics, metabolism) Nevus (genetics, pathology) Nuclear Proteins Ploidies Proto-Oncogene Proteins (genetics, metabolism) Skin Neoplasms (genetics, pathology)

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