Abstract | BACKGROUND: AIM: MATERIAL: METHOD:
Autoantibodies to beta1-adrenoreceptor were determined in patient's blood serum by direct immunoassay. Synthetic fragment containing 26 amino acids of the beta1-adrenoreceptor second loop was used as antigen. RESULTS: Ten patients had obviously elevated content of autoantibodies. Three of these patients had IHD, 3 - DCM, 1 was studied 6 moths after myocarditis and 3 - 6-9 years after cardiac transplantation. Tests were repeated with intervals from 6 months to 1 year and levels of autoantibodies remained elevated in all these patients. Detection of antibodies did not depend on the etiology of systolic cardiac failure (IHD, DCM), severity of hemodynamic impairment, presence of disorders of cardiac rhythm or conduction.
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Authors | E A Tabak'ian, V V Kukharchuk, V G Naumov, S L Dzemeshkevich, P Iu Perov, A G Tonevitskiĭ, Iu N Belenkov, V I Shumakov |
Journal | Kardiologiia
(Kardiologiia)
Vol. 42
Issue 6
Pg. 42-6
( 2002)
ISSN: 0022-9040 [Print] Russia (Federation) |
Vernacular Title | Chastota vyiavleniia autoantitel k beta1-adrenoretseptoram u bol'nykh s miokarditami i kardiomiopatiiami. |
PMID | 12494129
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Autoantibodies
- Receptors, Adrenergic, beta-1
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Topics |
- Autoantibodies
(immunology)
- Cardiomyopathies
(epidemiology, immunology, physiopathology)
- Female
- Heart Rate
(physiology)
- Humans
- Male
- Middle Aged
- Myocarditis
(epidemiology, immunology, physiopathology)
- Prevalence
- Receptors, Adrenergic, beta-1
(immunology)
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