Intracranial tuberculoma in a liver transplant patient: first reported case and review of the literature.

Abstract

A 66-year-old female who had undergone an orthotopic liver transplant two years before admission was admitted with fever and neurological symptoms of several days' duration. Following an extensive work-up, which revealed positive intracranial lesions on computed typography and magnetic resonance imaging, the patient was begun on broad spectrum antimicrobials including corticosteroids. The patient responded though the etiology of infection remained unclear. After a stereotactic biopsy was performed revealing granulomas and acid-fast bacilli, the patient was started on antituberculous medications. A review of the literature reveals that the rare occurrence of intracranial tuberculoma should be considered in an orthotopic liver transplant (OLT) patient with central nervous system pathology.

• Authors: Corey Henderson, Burt Meyers, S Humayun Gultekin, Bin Liu, David Y Zhang
• Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (Am J Transplant) Vol. 3 Issue 1 Pg. 88-93 (Jan 2003) ISSN: 1600-6135 [Print] United States
• PMID: 12492718 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Brain (microbiology, pathology)
• Diabetes Mellitus, Type 2
• Female
• Humans
• Liver Transplantation
• Mycobacterium tuberculosis
• Tomography, X-Ray Computed
• Tuberculoma, Intracranial