[A study on the use of mycobacterium vaccine in the treatment of tuberculous pleurisy].
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| Abstract | OBJECTIVE: To study the effects of immunotherapy with mycobacterium vaccine in patients with tuberculous pleurisy. METHODS: The time for effusion resolution and lymphocyte counts in the effusions were observed in patients with tuberculous pleurisy who received anti-tuberculous therapy and thoracentesis (group A) or anti-tuberculous therapy and thoracentesis plus intramuscularly administered polysaccharide nucleic acid fraction of Bacillus Calmette Guerin (PSN-BCG,) (group S). In situ end-labeling technique of fragment DNA was used to detect the apoptosis of lymphocytes in the effusions. RESULTS: The average resolution times in group A and group S were 21.2 days and 28.7 days respectively (P < 0.01). The lymphocyte counts in the two groups after 1 week, 2 week, and 3 week therapy were 1.6 x 10(9)/L (A) and 2.1 x 10(9)/L (S) (P < 0.01), 0.83 x 10(9)/L and 1.52 x 10(9)/L (P < 0.01), 0.55 x 10(9)/L and 1.16 x 10(9)/L (P < 0.01) respectively. The average apoptotic half-time was 94 h (A) and 124 h (S) (P < 0.01), 84 h and 123 h (P < 0.01), 79 h and 120 h (P < 0.01) respectively. CONCLUSIONS: Mycobacterium vaccine was found to prolong lymphocyte activation, inhibit lymphocyte apoptosis, and delay the resolution of pleural effusions. It was found not helpful as an adjunct therapy for tuberculous pleurisy.
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| Authors | Xiangdong Zhou, Jian Lan, Ting Zhang |
| Journal | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases (Zhonghua Jie He He Hu Xi Za Zhi) Vol. 25 Issue 10 Pg. 595-7 (Oct 2002) ISSN: 1001-0939 [Print] China |
| PMID | 12490125 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial) |
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