Measurement error of visual field tests in glaucoma.

Psychophysical strategies designed for clinical visual field testing produce rapid estimates of threshold with relatively few stimulus presentations and so represent a trade-off between test quality and efficiency. The aim of this study was to determine the measurement error of a staircase algorithm similar to full threshold with standard automated perimetry (SAP) and frequency doubling perimetry (FDP) in glaucoma patients.
Seven patients with early open angle glaucoma (OAG) were prospectively recruited. All were experienced in laboratory based psychophysics. Three matched test locations were examined with SAP (externally driven Humphrey field analyser) and FDP (CRT) in a single arbitrarily selected eye of each subject. Each location was tested twice with a 4-2-2 dB staircase strategy, similar to full threshold, and then with the method of constant stimuli (MOCS). Accuracy (threshold estimation error) was quantified by determination of differences between "true" threshold measurements made by MOCS and single staircase threshold estimates. Precision (repeatability) was quantified by the differences between repeated staircase threshold estimates.
Precision was relatively high for both tests, although higher for FDP than SAP at depressed sensitivity levels. The staircase strategy significantly underestimated threshold sensitivity for both test types, with the mean difference (95% CI) between staircase and MOCS thresholds being 4.48 dB (2.35 to 7.32) and 1.35 dB (0.56 to 1.73) for SAP and FDP respectively. Agreement levels (weighted kappa) between MOCS and staircase thresholds were found to be 0.48 for SAP and 0.85 for FDP. Although this "bias" appeared constant for FDP across all sensitivity levels, this was not the case for SAP where accuracy decreased at lower sensitivity levels.
Estimations of threshold sensitivity made using staircase strategies common to clinical visual field test instrumentation are associated with varying degrees of measurement error according to visual field test type and sensitivity. In particular, SAP significantly overestimates the "true" level of sensitivity, particularly in damaged areas of the visual field, suggesting that clinical data of this type should be interpreted with caution.
AuthorsP G D Spry, C A Johnson, A M McKendrick, A Turpin
JournalThe British journal of ophthalmology (Br J Ophthalmol) Vol. 87 Issue 1 Pg. 107-12 (Jan 2003) ISSN: 0007-1161 [Print] England
PMID12488273 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
  • Aged
  • Aged, 80 and over
  • Female
  • Glaucoma, Open-Angle (physiopathology)
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Psychophysics (methods)
  • Reproducibility of Results
  • Sensory Thresholds (physiology)
  • Vision Tests (standards)
  • Visual Field Tests (methods)
  • Visual Fields (physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: