Abstract | BACKGROUND: METHODS:
Botulinum toxin A injections were applied to 16 patients with blepharospasm. All patients complained of dry eye symptoms and had reduced tear break up time values. A subjective questionnaire and ocular examinations including tear break up time, Schirmer test without local anaesthesia, and rose bengal staining were evaluated before, 1 week, 1 month, and 3 months after injection. Impression cytology was performed before, 1 month, and 3 months after botulinum toxin A treatment. RESULTS: Although all patients were relieved of blepharospasm after botulinum toxin injections, only three noticed an improvement in dry eye symptoms. Eight patients noticed no difference and five complained of worsening. Tear break up time was found to be increased 1 week and 1 month after injections. Schirmer test measurements were reduced up to 3 months. Rose bengal staining slightly increased 1 week after injections. Impression cytology showed no definite change in conjunctival cell morphology 1 month and 3 months after botulinum toxin A injections. CONCLUSION:
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Authors | J Horwath-Winter, J Bergloeff, I Floegel, E-M Haller-Schober, O Schmut |
Journal | The British journal of ophthalmology
(Br J Ophthalmol)
Vol. 87
Issue 1
Pg. 54-6
(Jan 2003)
ISSN: 0007-1161 [Print] England |
PMID | 12488263
(Publication Type: Journal Article)
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Chemical References |
- Neuromuscular Agents
- Botulinum Toxins, Type A
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Blepharospasm
(drug therapy, pathology)
- Botulinum Toxins, Type A
(therapeutic use)
- Conjunctiva
(pathology)
- Dry Eye Syndromes
(drug therapy, pathology)
- Epithelium
(pathology)
- Female
- Humans
- Male
- Metaplasia
(pathology)
- Middle Aged
- Neuromuscular Agents
(therapeutic use)
- Tears
(metabolism)
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