Abstract | BACKGROUND: OBJECTIVE: METHODS: Randomized, double blind, placebo-controlled, two-way crossover study in 20 subjects with seasonal allergic rhinitis, out of their allergy season (median age 27.5 years, 13 males and 7 females). Subjects were medicated with either placebo or fexofenadine 180 mg orally daily for 1 week followed by nasal challenge with allergen. After each challenge, sneezes and nasal symptoms were recorded, and a nasal lavage was obtained for the assay of albumin, an indicator of vascular permeability, and histamine and tryptase, indicators of mast cell degranulation. RESULTS: When patients were on placebo, allergen challenges led to significant increases in all measured parameters compared with the sham challenges with diluent. Treatment with fexofenadine resulted in inhibition of allergen-induced symptoms and increased vascular permeability, but not the release of histamine and tryptase. CONCLUSION:
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Authors | Frances T Allocco, Virginia Votypka, Marcy deTineo, Robert M Naclerio, Fuad M Baroody |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 89
Issue 6
Pg. 578-84
(Dec 2002)
ISSN: 1081-1206 [Print] United States |
PMID | 12487223
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Allergens
- Biomarkers
- Histamine H1 Antagonists
- Serum Albumin
- Terfenadine
- fexofenadine
- Serine Endopeptidases
- Tryptases
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Topics |
- Adolescent
- Adult
- Allergens
- Biomarkers
- Capillary Permeability
(drug effects)
- Cross-Over Studies
- Double-Blind Method
- Female
- Histamine H1 Antagonists
(chemistry, pharmacology)
- Histamine Release
(drug effects)
- Humans
- Male
- Mast Cells
(drug effects, metabolism)
- Middle Aged
- Molecular Structure
- Nasal Cavity
- Nasal Provocation Tests
- Pruritus
(etiology)
- Rhinitis, Allergic, Seasonal
(drug therapy)
- Serine Endopeptidases
(metabolism)
- Serum Albumin
(analysis)
- Sneezing
- Structure-Activity Relationship
- Terfenadine
(analogs & derivatives, chemistry, pharmacology)
- Therapeutic Irrigation
- Tryptases
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