Abstract |
The aim of this study was to evaluate the timing of onset and the duration of action of a single oral-dose treatment with montelukast in comparison to placebo on exercise-induced asthma (EIA) in asthmatic children. Nineteen children (7-13 years) with stable asthma were evaluated. Patients undertook three consecutive treadmill exercise tests, respectively, 2, 12 and 24 h after a single-dose administration. A double-blind randomized, single-dose, placebo-controlled, crossover design was used. To assess bronchoconstriction after the exercise challenge, the maximal percentage fall in FEV1 (DeltaFEV1) from the baseline value was considered. Two hours after dosing, DeltaFEV1 was -15.33 +/- 2.93 for placebo and -13.33 +/- 2.03 for montelukast. At 12 h, DeltaFEV1 was -18.69 +/- 2.83 for placebo, -9.78 +/- 1.85 for montelukast (p < 0.005). No difference was observed between placebo (DeltaFEV1-10.21 +/- 2.07) and montelukast (DeltaFEV1-9.10 +/- 2.02) at 24 h. Analysis of the degree of protection showed a significant efficacy of montelukast (p = 0.02) in comparison with placebo only at 12 h. Montelukast showed a significant protective effect 12 h after dosing, but no effect after 2 and 24 h. In mild asthmatics, the timing of administration of single dosage before exercise should be strictly considered in order to obtain the drug protective effects.
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Authors | Diego G Peroni, Giorgio L Piacentini, Michela Ress, Alessandro Bodini, Attilio Loiacono, Raffaele Aralla, Attilio L Boner |
Journal | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
(Pediatr Allergy Immunol)
Vol. 13
Issue 6
Pg. 434-7
(Dec 2002)
ISSN: 0905-6157 [Print] England |
PMID | 12485319
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Acetates
- Cyclopropanes
- Leukotriene Antagonists
- Quinolines
- Sulfides
- montelukast
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Topics |
- Acetates
(administration & dosage)
- Adolescent
- Asthma, Exercise-Induced
(drug therapy, physiopathology)
- Child
- Child Welfare
- Cross-Over Studies
- Cyclopropanes
- Dose-Response Relationship, Drug
- Double-Blind Method
- Exercise Test
- Female
- Forced Expiratory Volume
(drug effects, physiology)
- Humans
- Leukotriene Antagonists
(administration & dosage)
- Male
- Quinolines
(administration & dosage)
- Sulfides
- Time Factors
- Treatment Outcome
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