Abstract |
A 39-year-old woman visited us because of a subcutaneous induration on her forehead of 7 months' duration. The tumor was tender, firm, and colored blue-black. Microscopically, the tumor was composed of fibroblastic and histiocytic cells showing no atypicality. In some part intra- or extracellular haemosiderin was diffusely seen. There were some blood-filled spaces of varying size without endothelial lining. From these findings, this case was diagnosed as aneurysmal fibrous histiocytoma (AFH), a variant form of dermatofibroma. Immunohistochemical analysis showed that factor XIIIa-positive histiocytic cells were distributed in the area without haemosiderin, but such cells were absent in the area with its deposition. Furthermore, the cells near the blood-filled space showed transition from factor XIIIa-positive to -negative, suggesting that the stromal instability induced by the attenuation of factor XIII may lead the formation of the blood-filled spaces in AFH.
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Authors | Shigeki Inui, Satoshi Itami, Kunihiko Yoshikawa |
Journal | The Journal of dermatology
(J Dermatol)
Vol. 29
Issue 11
Pg. 744-7
(Nov 2002)
ISSN: 0385-2407 [Print] England |
PMID | 12484439
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Biopsy, Needle
- Diagnosis, Differential
- Factor XIIIa
(analysis)
- Female
- Forehead
- Hemangioma
(diagnosis)
- Histiocytoma, Benign Fibrous
(diagnosis, pathology, surgery)
- Humans
- Immunohistochemistry
- Melanoma
(diagnosis)
- Skin Neoplasms
(diagnosis, pathology, surgery)
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