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Aneurysmal fibrous histiocytoma showing transition from factor XIIIa-positive to -negative.

Abstract
A 39-year-old woman visited us because of a subcutaneous induration on her forehead of 7 months' duration. The tumor was tender, firm, and colored blue-black. Microscopically, the tumor was composed of fibroblastic and histiocytic cells showing no atypicality. In some part intra- or extracellular haemosiderin was diffusely seen. There were some blood-filled spaces of varying size without endothelial lining. From these findings, this case was diagnosed as aneurysmal fibrous histiocytoma (AFH), a variant form of dermatofibroma. Immunohistochemical analysis showed that factor XIIIa-positive histiocytic cells were distributed in the area without haemosiderin, but such cells were absent in the area with its deposition. Furthermore, the cells near the blood-filled space showed transition from factor XIIIa-positive to -negative, suggesting that the stromal instability induced by the attenuation of factor XIII may lead the formation of the blood-filled spaces in AFH.
AuthorsShigeki Inui, Satoshi Itami, Kunihiko Yoshikawa
JournalThe Journal of dermatology (J Dermatol) Vol. 29 Issue 11 Pg. 744-7 (Nov 2002) ISSN: 0385-2407 [Print] England
PMID12484439 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Factor XIIIa
Topics
  • Adult
  • Biopsy, Needle
  • Diagnosis, Differential
  • Factor XIIIa (analysis)
  • Female
  • Forehead
  • Hemangioma (diagnosis)
  • Histiocytoma, Benign Fibrous (diagnosis, pathology, surgery)
  • Humans
  • Immunohistochemistry
  • Melanoma (diagnosis)
  • Skin Neoplasms (diagnosis, pathology, surgery)

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