Abstract |
We have previously shown that sex and obesity independently affect basal very low density lipoprotein ( VLDL)-triglyceride (TG) kinetics. In the present study, we investigated the effect of hyperglycemia- hyperinsulinemia on VLDL-TG kinetics in lean and obese men and women (n = 6 in each group). VLDL-TG kinetics were measured during basal, postabsorptive conditions and during glucose infusion (5.5 mg x kg FFM(-1) x min(-1)) by using [(2)H(5)] glycerol bolus injection in conjunction with compartmental modeling analysis. Basal VLDL-TG secretion in plasma was greater in obese than in lean men (7.8 +/- 0.6 and 2.9 +/- 0.4 micromol x l plasma(-1) x min(-1); P < 0.001) but was not different in lean and obese women (5.0 +/- 1.1 and 5.9 +/- 1.1 micromol x l plasma(-1) x min(-1)). Glucose infusion decreased the VLDL-TG secretion rate by approximately 50% in lean and obese men and in lean women (to 1.5 +/- 0.4, 4.0 +/- 0.6, and 2.2 +/- 0.4 micromol x l plasma(-1) x min(-1), respectively; all P < 0.05) but had no effect on the VLDL-TG secretion rate in obese women (4.9 +/- 1.0 micromol x l plasma(-1) x min(-1)). These results demonstrate that both sex and adiposity affect the regulation of VLDL-TG metabolism. Glucose and insulin decrease VLDL-TG production in both lean men and lean women; obesity is associated with resistance to the glucose- and insulin-mediated suppression of VLDL-TG secretion in women, but not in men.
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Authors | Bettina Mittendorfer, Bruce W Patterson, Samuel Klein, Labros S Sidossis |
Journal | American journal of physiology. Endocrinology and metabolism
(Am J Physiol Endocrinol Metab)
Vol. 284
Issue 4
Pg. E708-15
(Apr 2003)
ISSN: 0193-1849 [Print] United States |
PMID | 12475756
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Blood Glucose
- Cholesterol, VLDL
- Fatty Acids
- Insulin
- Triglycerides
- Glucose
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Topics |
- Adult
- Blood Glucose
(metabolism)
- Cholesterol, VLDL
(blood)
- Coronary Disease
(metabolism)
- Fatty Acids
(blood)
- Female
- Glucose
(administration & dosage)
- Humans
- Hyperglycemia
(metabolism)
- Hyperinsulinism
(metabolism)
- Insulin
(blood)
- Insulin Resistance
- Kinetics
- Male
- Obesity
(metabolism)
- Sex Factors
- Triglycerides
(blood)
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