Abstract | BACKGROUND: Preoperative localisation is important for successful surgical treatment of gastrinomas. However, a satisfactory method that achieves this has not been defined, and at present somatostatin receptor scintigraphy and selective intra-arterial stimulation testing with secretin have the greatest sensitivities. As secretin is now difficult to obtain, we decided to explore the use of calcium gluconate as a secretagogue. High extracellular calcium concentrations cause degranulation of neuroendocrine cells and subsequent release of hormone. METHODS: Two patients with biochemically proven gastrinomas were investigated pre-operatively. Under angiographic control calcium gluconate was injected into the arteries supplying the pancreas and duodenum, gastrin levels were then determined in hepatic vein samples obtained before and 30, 60, 90, 120 and 180 seconds after each injection. One of the patients had also previously undergone selective intra-arterial stimulation testing with secretin. RESULTS: CONCLUSIONS:
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Authors | J J O Turner, A M Wren, J E Jackson, R V Thakker, K Meeran |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 57
Issue 6
Pg. 821-5
(Dec 2002)
ISSN: 0300-0664 [Print] England |
PMID | 12460333
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gastrins
- Calcium Gluconate
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Topics |
- Adult
- Angiography
- Calcium Gluconate
- Duodenal Neoplasms
(diagnosis, metabolism)
- Duodenum
(blood supply, diagnostic imaging)
- Female
- Gastrinoma
(diagnosis, metabolism)
- Gastrins
(blood, metabolism)
- Hepatic Veins
- Humans
- Injections, Intra-Arterial
- Male
- Middle Aged
- Multiple Endocrine Neoplasia Type 1
(blood)
- Pancreas
(blood supply, diagnostic imaging)
- Sensitivity and Specificity
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