[Results of the treatment of childhood acute lymphoblastic leukemia according to the Berlin-Moscow-91 protocol in 1991-2000].

Abstract

The report deals with the results of application of an original protocol--the Berlin-Moscow-91 (BM-91)--for the treatment of acute lymphoblastic leukemia (ALL) in children. The researchers' major concern was to improve survival and cut down side-effects incidence as well as to prevent and successfully manage occult neuroleukemia as a potential source of relapse. Patients aged 5 months-15 years received the BM-91 and ALL BFM-90m treatment first at one clinic and later at several centers. Out of 852 children with primary diagnosis of ALL admitted to Russian hematological hospitals (March 2, 1991-November 3, 2000), 687 were included into the study; 329 received the MB-91 protocol. Nine-year recurrence-free survival was 73% while overall survival--80%. Toxic side-effects after L-asparaginase were reported in 27 (7.9%). It is concluded that good results in childhood ALL treatment can be achieved without resorting to high-dosage chemotherapy and radiation in most cases.

• Authors: N V Miakova, R Hartmann, A E Rudneva, N M Trubina, L G Fechina, A M Timakov, A V Shamardina, V V Lebedev, S R Varfolomeeva, S D Dudkin, Z M Dyshlevaia, V N Timofeeva, A G Rumiantsev, H Henze, A I Karachunskiĭ
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 48 Issue 3 Pg. 340-6 ( 2002) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Rezul'taty lecheniia ostrogo limfoblastnogo leĭkoza u deteĭ po protokolu Moskva-Berlin-91 v 1991-2000 gg.
• PMID: 12455359 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Antimetabolites, Antineoplastic
• Antineoplastic Agents
• Antineoplastic Agents, Hormonal
• Antineoplastic Agents, Phytogenic
• Cytarabine
• Vincristine
• Dexamethasone
• Mercaptopurine
• Asparaginase
• Methotrexate
• Daunorubicin

Topics

• Adolescent
• Antimetabolites, Antineoplastic (administration & dosage)
• Antineoplastic Agents (administration & dosage)
• Antineoplastic Agents, Hormonal (administration & dosage)
• Antineoplastic Agents, Phytogenic (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols
• Asparaginase (administration & dosage)
• Child
• Child, Preschool
• Cytarabine (administration & dosage)
• Data Interpretation, Statistical
• Daunorubicin (administration & dosage)
• Dexamethasone (administration & dosage)
• Female
• Follow-Up Studies
• Humans
• Infant
• Male
• Mercaptopurine (administration & dosage)
• Methotrexate (administration & dosage)
• Moscow
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (drug therapy, mortality)
• Remission Induction
• Risk Factors
• Russia
• Survival Analysis
• Time Factors
• Vincristine (administration & dosage)