Abstract |
Medroxyprogesterone acetate (MPA) and acetazolamide (ACET) are two ventilatory stimulants which are used in hypoxic and hypercapnic patients with chronic obstructive pulmonary disease ( COPD). In a double-blind randomised study, the effects of a 2-week treatment with MPA (30 mg b.i.d.) or ACET (250 mg b.i.d.), followed by a 2-week treatment with a combination of both drugs (MPA/ACET), on daytime and nocturnal ventilatory and blood gas parameters in 17 stable hypercapnic COPD patients were investigated. ACET, MPA and MPA/ACET treatment decreased mean daytime carbon dioxide tension in arterial blood by 0.4, 0.7 and 1.2 kPa, respectively. Minute ventilation was improved only with combined therapy, from 9.3 to 11.2 L x min(-1). With MPA/ACET therapy, the hypercapnic and hypoxic ventilatory responses significantly increased, from 3.7 to 5.8 L x min(-1) x kPa(-1) and from -0.13 to -0.40 L x min(-1) x %(-1), respectively. The mouth exclusion pressure response to hypoxia increased during combination therapy, from -0.01 to -0.03 kPa %(-1). Nocturnal end-tidal carbon dioxide tension decreased with MPA and MPA/ACET treatment, by 0.9 and 1.4 kPa, respectively. MPA/ACET significantly increased mean nocturnal arterial oxygen saturation values, from 85.5 to 90.2%. The authors conclude that short-term combined treatment with medroxyprogesterone acetate and acetazolamide has a more favourable effect on day and night-time blood gas values and chemical drive than single drug treatment.
|
Authors | M Wagenaar, P Je Vos, Y F Heijdra, L J Teppema, H T M Folgering |
Journal | The European respiratory journal
(Eur Respir J)
Vol. 20
Issue 5
Pg. 1130-7
(Nov 2002)
ISSN: 0903-1936 [Print] England |
PMID | 12449165
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Carbonic Anhydrase Inhibitors
- Carbon Dioxide
- Medroxyprogesterone
- Acetazolamide
- Oxygen
|
Topics |
- Acetazolamide
(administration & dosage)
- Aged
- Carbon Dioxide
(blood)
- Carbonic Anhydrase Inhibitors
(administration & dosage)
- Double-Blind Method
- Drug Therapy, Combination
- Humans
- Hypercapnia
(complications, drug therapy, physiopathology)
- Hypoxia
(complications, drug therapy, physiopathology)
- Medroxyprogesterone
(administration & dosage)
- Oxygen
(blood)
- Pulmonary Disease, Chronic Obstructive
(complications, drug therapy, physiopathology)
- Respiration
(drug effects)
|