Abstract | OBJECTIVE: METHODS: In a rat lung transplant model animals were randomized into 2 groups defined by the ventilatory strategy during the early reperfusion period. In conventional mechanical ventilation the transplanted lung was ventilated with a tidal volume equal to 50% of the inspiratory capacity of the left lung and a low positive end-expiratory pressure. In minimal mechanical stress ventilation the transplanted lung was ventilated with a tidal volume equal to 20% of the inspiratory capacity of the left lung, and positive end-expiratory pressure was adjusted according to the shape of the pressure-time curve to minimize pulmonary stress. RESULTS: After 3 hours of reperfusion, oxygenation from the transplanted lung was significantly higher with minimal mechanical stress ventilation than with conventional ventilation. In addition, elastance, cytokine levels, and morphologic signs of injury were significantly lower in the group with minimal mechanical stress ventilation. CONCLUSIONS:
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Authors | Marc de Perrot, Yumiko Imai, George A Volgyesi, Thomas K Waddell, Mingyao Liu, J Brendan Mullen, Karen McRae, Haibo Zhang, Arthur S Slutsky, V Marco Ranieri, Shaf Keshavjee |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 124
Issue 6
Pg. 1137-44
(Dec 2002)
ISSN: 0022-5223 [Print] United States |
PMID | 12447179
(Publication Type: Journal Article)
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Topics |
- Animals
- Lung Transplantation
- Male
- Pulmonary Gas Exchange
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Reperfusion Injury
(etiology)
- Respiration, Artificial
(methods)
- Respiratory Mechanics
- Stress, Mechanical
- Ventilators, Mechanical
(adverse effects)
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