Efficacy of leukemia inhibitory factor in experimental autoimmune neuritis.

Abstract

Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that exerts neurotrophic and myotrophic actions. We have investigated the effect of LIF in experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome (GBS). Treatment with LIF at the onset of the disease showed a slight, but not significant, improvement in the clinical course but no effect on nerve histology.

• Authors: M Laurà, N A Gregson, Y Curmi, R A C Hughes
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 133 Issue 1-2 Pg. 56-9 (Dec 2002) ISSN: 0165-5728 [Print] Netherlands
• PMID: 12446008 (Publication Type: Journal Article)

Chemical References

• Growth Inhibitors
• Interleukin-6
• Leukemia Inhibitory Factor
• Lymphokines

Topics

• Animals
• Axons (drug effects, immunology, pathology)
• Body Weight (drug effects, immunology)
• Cauda Equina (drug effects, immunology, pathology)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Growth Inhibitors (pharmacology, therapeutic use)
• Guillain-Barre Syndrome (drug therapy)
• Interleukin-6
• Leukemia Inhibitory Factor
• Lymphokines (pharmacology, therapeutic use)
• Myelin Sheath (drug effects, immunology, pathology)
• Neuritis, Autoimmune, Experimental (drug therapy, pathology, physiopathology)
• Rats
• Sciatic Nerve (drug effects, immunology, pathology)
• Spinal Nerve Roots (drug effects, immunology, pathology)
• Treatment Outcome
• Wallerian Degeneration (drug therapy, immunology, pathology)