Abstract | OBJECTIVE: DESIGN: Descriptive case report and review of the literature. SETTING: Medical intensive care unit in a university medical center. PATIENT AND MAIN RESULTS: A 75-yr-old woman developed a first episode of toxic epidermal necrolysis (involving 40% of the body surface) after intake of cefotaxime, a third-generation cephalosporin. Perfusions of high-dose immunoglobulins rapidly improved the lesions, followed by partial reepithelialization in 5 days. Sepsis required the administration of meropenem, which is a carbapenem antibiotic. The epidermal destruction immediately recurred, with extension to previously uninvolved skin areas and fatal consequences. CONCLUSIONS:
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Authors | Philippe Paquet, Eric Jacob, Pierre Damas, Gérald E Piérard |
Journal | Critical care medicine
(Crit Care Med)
Vol. 30
Issue 11
Pg. 2580-3
(Nov 2002)
ISSN: 0090-3493 [Print] United States |
PMID | 12441773
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Thienamycins
- Meropenem
- Cefotaxime
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Topics |
- Aged
- Anti-Bacterial Agents
(adverse effects, pharmacology)
- Cefotaxime
(adverse effects, pharmacology)
- Drug Interactions
- Fatal Outcome
- Female
- Humans
- Meropenem
- Stevens-Johnson Syndrome
(etiology)
- Thienamycins
(adverse effects, pharmacology)
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