[MRI findings and effectiveness of cyproheptadine in two patients with ophthalmoplegic migraine].

Abstract

We reported the MRI findings and clinical course of two patients with ophthalmoplegic migraine. Both patients presented with unilateral oculomotor nerve palsy. Contrast enhanced MR imaging revealed unilateral enhancement and thickening of the oculomotor nerve in one patient. Prednisolone was effective in both patients, but only could transiently. On the other hand, cyproheptadine hydrochloride could completely prevent recurrent attacks of ophthalmoplegic migraine. Thus, MR imaging with of contrast enhancement is useful in the diagnosis of ophthalmoplegic migraine. Cyproheptadine hydrochloride is better than prednisolone to prevention recurrent attacks and to avoid adverse effects.

• Authors: Nobuyoshi Sugiyama, Shin-ichiro Hamano, Manabu Tanaka, Mika Mochizuki, Takahiro Nara
• Journal: No to hattatsu = Brain and development (No To Hattatsu) Vol. 34 Issue 6 Pg. 533-7 (Nov 2002) ISSN: 0029-0831 [Print] Japan
• PMID: 12440104 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Histamine H1 Antagonists
• Cyproheptadine

Topics

• Child
• Child, Preschool
• Cyproheptadine (therapeutic use)
• Female
• Histamine H1 Antagonists (therapeutic use)
• Humans
• Magnetic Resonance Imaging
• Male
• Migraine Disorders (diagnosis, drug therapy)
• Ophthalmoplegia (complications)