Dose-reduced conditioning regimen followed by allogeneic stem cell transplantation in patients with myelofibrosis with myeloid metaplasia.

Abstract

Three patients with myelofibrosis received allogeneic stem cell transplantation after a dose-reduced conditioning regimen of busulphan (8 mg/kg), fludarabine (180 mg/m2) and antithymocyte globulin (4 x 10 mg/kg). The median age at transplantation was 51 years (range 44-58). All patients engrafted with a leucocyte count > 1.0 x 10(9)/l after a median of 18 d (range 16-20). Grade II acute skin graft-versus-host disease (GvHD) occurred in one patient. One limited and one extensive chronic GvHD was observed. All patients achieved complete haematological remission. In one patient the fibrosis resolved completely 180 d post transplant. All patients are alive 126, 466 and 764 d after transplantation.

• Authors: Jörg Hessling, Nicolaus Kröger, Mathias Werner, Tatjana Zabelina, Arne Hansen, Uwe Kordes, Francis Ayuketang Ayuk, Helmut Renges, Jörg Panse, Rudolf Erttmann, Axel Rolf Zander
• Journal: British journal of haematology (Br J Haematol) Vol. 119 Issue 3 Pg. 769-72 (Dec 2002) ISSN: 0007-1048 [Print] England
• PMID: 12437657 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vidarabine
• Busulfan
• fludarabine

Topics

• Adult
• Busulfan (administration & dosage)
• Dose-Response Relationship, Drug
• Female
• Graft vs Host Disease (prevention & control)
• Hematopoietic Stem Cell Transplantation (methods)
• Humans
• Male
• Middle Aged
• Primary Myelofibrosis (complications, therapy)
• Transplantation Conditioning (methods)
• Transplantation, Homologous
• Treatment Outcome
• Vidarabine (administration & dosage, analogs & derivatives)