The long-term efficacy of
testosterone supplementation for
erectile dysfunction was evaluated using standardized questionnaires and differences between
testosterone delivery systems analyzed. Forty-four patients receiving parenteral
depo-testosterone,
Testoderm scrotal patches, or
Testoderm-TTS nonscrotal patches were evaluated with the
Erectile Dysfunction Inventory of Treatment Satisfaction and International Index of Erectile Function questionnaires. Global questions regarding libido, energy, and improved erections demonstrated a significantly better response with
depo-testosterone and
Testoderm-TTS nonscrotal patches as compared to
Testoderm scrotal patches.
Testoderm-TTS nonscrotal patches and
depo-testosterone resulted in significantly higher overall treatment satisfaction (p <.001), confidence in ability to engage in sexual activity (p <.001), and total
Erectile Dysfunction Inventory of Treatment Satisfaction and International Index of Erectile Function scores (p <.001).
Testoderm-TTS nonscrotal patches were significantly better than
depo-testosterone with regard to satisfaction with sexual intercourse (International Index of Erectile Function question 5, p <.05).
Testosterone replacement improved the quality of erections and level of libido in patients with
erectile dysfunction. Treatment delivery systems appear to impact the success of
therapy.