Association between -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene and fluvoxamine response in Japanese patients with major depressive disorder.
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| Abstract |
Genetic polymorphism of the serotonin 5-HT(2A) receptor seems to be associated with therapeutic response to selective serotonin reuptake inhibitors (SSRIs). The present study investigated whether a novel -1438G/A polymorphism in the promoter region of the 5-HT(2A )receptor gene is associated with therapeutic response to fluvoxamine (an SSRI) in 66 Japanese patients with major depressive disorder. Fluvoxamine (50 to 200 mg) was administered twice daily for 6 weeks. Fifty-four patients completed this study. The genotype distribution and the allele frequencies showed no significant difference between responders and non-responders. The time-course of the Montgomery-Asberg Depression Rating Scale scores showed no significant difference among -1438G/G, -1438G/A, and -1438A/A genotype groups. The results demonstrated that the -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene was unlikely to have a major role in therapeutic response to fluvoxamine in Japanese patients with major depressive disorder.
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| Authors | Kazuhiro Sato, Keizo Yoshida, Hitoshi Takahashi, Kenichi Ito, Mitsuhiro Kamata, Hisashi Higuchi, Tetsuo Shimizu, Kunihiko Itoh, Kazuyuki Inoue, Takehiko Tezuka, Toshio Suzuki, Taashi Ohkubo, Kazunobu Sugawara, Koichi Otani |
| Journal | Neuropsychobiology (Neuropsychobiology) Vol. 46 Issue 3 Pg. 136-40 ( 2002) ISSN: 0302-282X [Print] Switzerland |
| PMID | 12422060 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright 2002 S. Karger AG, Basel |
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