[Clinical study of the combination of small amount of nedaplatin (CDGP)/5-FU with radiation for the treatment of esophageal cancer].
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| Abstract |
Recently chemoradiotherapy for esophageal cancer has been drawing public attention to the issue of quality of life maintenance for patients. Although the standard method of chemoradiotherapy is CDDP/5FU, it has been claimed that CDGP (a derivative of CDDP) alone is more effective than CDDP for the treatment of esophageal cancer due to its low nephro- and digestive toxicity. We used a small amount of CDGP/5-FU in combination with radiation instead of CDDP, for the treatment of esophageal cancer and performed clinical examination of patients. The partial response rate was 80% and the complete response rate was 50%. Major side-effects were leukopenia, neutropenia, thrombocytopenia and anemia. Further study of dosage and schedule is necessary, however, CDGP/5-FU combined with radiation therapy could be used as choices of chemoradiotherapy for esophageal cancer in the future.
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| Authors | Hiroyuki Inaba, Takashi Tsuda, Aya Miyazaki, Yoshiyuki Watanabe, Shinichi Nakaya, Yu Koitabashi, Kyoko Ogihara, Takefumi Hara, Naoyuki Kato, Yutaro Kobayashi, Teisuke Nakagawa, Satoshi Kitajima, Toru Endo, Shiro Iino, Yoshikazu Hoshikawa |
| Journal | Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 99 Issue 10 Pg. 1191-6 (Oct 2002) ISSN: 0446-6586 [Print] Japan |
| PMID | 12415854 (Publication Type: English Abstract, Journal Article) |
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