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A clinical study of eosinophilic meningoencephalitis caused by angiostrongyliasis.

AbstractOBJECTIVE:
To improve the clinician's awareness of angiostrongyliasis.
METHODS:
The clinical and laboratory data as well as the epidemiological information concerning 18 patients with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis were analyzed.
RESULTS:
All patients had a history of eating raw fresh water snail (Ampularium canaliculatus) before the onset of the disease. Incubation period ranged from 1 to 25 days. The major symptoms of the patients had severe headache and pain in the trunk and limbs. Increased eosinophlic count in peripheral blood and cerebrospinal fluid was noted. Tested by enzyme-linked immunoadsorbent assay (ELISA), sera were specifically IgG-antibody positive against Angiostrougylus cantonensis antigen, but were negative against other parasitic antigens such as Paragonimus westermani, Cysticerus, Cellulosae hominis, Echinococcus granulosus and Trichinella spiralis. Abnormal spotty signals were found in 2 cases with brain magnetic resonance imaging. Electroencephalogram (EEG) showed slow alpha rhythm. All the patients were effectively treated with combined administration of albendazole and dexamethazone.
CONCLUSIONS:
Angiostrongyliasis is one of the common causes leading to eosinophilic meningoencephalitis. To our knowledge, Wenzhou is the first small outbreak site of angiostrongyliasis discovered in Chinese mainland.
AuthorsXiaotong Wang, Hanjin Huang, Qiqian Dong, Yan Lin, Zongmin Wang, Fangqu Li, Yukifumi Nawa, Kentars Yoshimura
JournalChinese medical journal (Chin Med J (Engl)) Vol. 115 Issue 9 Pg. 1312-5 (Sep 2002) ISSN: 0366-6999 [Print] China
PMID12411101 (Publication Type: Journal Article)
Chemical References
  • Dexamethasone
  • Albendazole
Topics
  • Adult
  • Albendazole (administration & dosage)
  • Angiostrongylus cantonensis
  • Animals
  • Dexamethasone (administration & dosage)
  • Eosinophilia (etiology)
  • Female
  • Humans
  • Male
  • Meningoencephalitis (etiology)
  • Middle Aged
  • Prognosis
  • Strongylida Infections (complications, drug therapy)

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