Anxiolytic and antiemetic activity of Zingiber officinale.

Abstract

The benzene fraction (BF) of a petroleum ether extract of dried rhizomes of ginger, which contained anticonvulsant principle(s), was screened for anxiolytic and antiemetic activity. Motor coordination was not affected by BF per se, but diazepam-induced motor incoordination was potentiated. Animals treated with BF showed decreased occupancy in the closed arm of the elevated plus maze suggesting the presence of anxiolytic principles in the BF. BF also blocked lithium sulphate-induced conditioned place aversion indicating antiemetic activity. These findings suggest that the fraction (BF) possesses anticonvulsant, anxiolytic and antiemetic activity.

• Authors: S L Vishwakarma, S C Pal, Veena S Kasture, S B Kasture
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 16 Issue 7 Pg. 621-6 (Nov 2002) ISSN: 0951-418X [Print] England
• PMID: 12410541 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2002 John Wiley & Sons, Ltd.

Chemical References

• Anti-Anxiety Agents
• Anticonvulsants
• Antiemetics
• Plant Extracts
• Pentylenetetrazole

Topics

• Animals
• Anti-Anxiety Agents (administration & dosage, pharmacology, therapeutic use)
• Anticonvulsants (administration & dosage, pharmacology, therapeutic use)
• Antiemetics (administration & dosage, pharmacology, therapeutic use)
• Avoidance Learning (drug effects)
• Ginger
• Male
• Maze Learning (drug effects)
• Motor Activity (drug effects)
• Pentylenetetrazole
• Phytotherapy
• Plant Extracts (administration & dosage, pharmacology, therapeutic use)
• Plant Roots
• Rats
• Rats, Sprague-Dawley
• Seizures (chemically induced, drug therapy)