Factors associated with the need for penetrating keratoplasty in keratoconus.

This study was designed to identify factors that may help to determine the likelihood of a patient with keratoconus undergoing a penetrating keratoplasty (PK) after referral to a cornea service.
A retrospective chart review of 109 patients from a corneal referral practice was undertaken to identify clinical characteristics at presentation that were predictive of subsequent PK.
Overall, during an average follow-up of 10.9 years, 39 (35.8%) did not have a PK for keratoconus in either eye, 34 (31.2%) had a PK in one eye, and 36 (33.0%) had a PK in both eyes. The presence of corneal scarring and steep keratometry values were significant risk factors for subsequent PK.
In a corneal referral practice, 64.2% of patients go on to PK in one or both eyes during long-term follow-up. The presence of scarring and high keratometry values at initial presentation may help to predict the likelihood of requiring a PK and may aid in patient counseling.
AuthorsWilliam A Sray, Elisabeth J Cohen, Christopher J Rapuano, Peter R Laibson
JournalCornea (Cornea) Vol. 21 Issue 8 Pg. 784-6 (Nov 2002) ISSN: 0277-3740 [Print] United States
PMID12410037 (Publication Type: Journal Article)
  • Adolescent
  • Adult
  • Aged
  • Child
  • Cornea (surgery)
  • Female
  • Humans
  • Keratoconus (surgery)
  • Keratoplasty, Penetrating
  • Likelihood Functions
  • Male
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Visual Acuity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: