Abstract | BACKGROUND: METHODS: Charts of 58 CKD veterans (glomerular filtration rate < 80 mL/min) administered at least 125 mg of sodium ferric gluconate complex in sucrose (SFGC) during a period of 1 year for the primary outcome of an increase in Hgb level by at least 0.5 g/dL were reviewed. RESULTS: Mean Hgb level at baseline was 10.5 +/- 1.4 (SD) g/dL (105 +/- 14 g/L) in the 30 patients administered recombinant human erythropoietin (rHuEPO) plus SFGC and 10.1 +/- 1.3 g/dL (101 +/- 13 g/L) in the 28 patients administered SFGC alone (P = not significant). The primary event occurred in 83% of the rHuEPO-plus-SFGC group at 31 days compared with 60% at 62 days in the group administered SFGC alone (P = 0.037, Cox F test). In patients administered SFGC alone, mean maximal Hgb level was 11.4 +/- 0.9 g/dL (114 +/- 9 g/L) in contrast to 12.4 +/- 1.7 g/dL (124 +/- 17 g/L) in the combination group, which remained significantly different even after adjustment for biologically important covariates (P = 0.01, analysis of covariance). Of the 240 doses of SFGC administered for which infusion records were available, 237 doses were well tolerated; three hypotensive episodes occurred in 2 patients, which did not result in discontinuation of the drug in either case. CONCLUSION: Correction of anemia with parenteral iron alone suggests a high prevalence of iron deficiency in patients with CKD. Treatment of concomitant iron deficiency with SFGC was well tolerated in patients with CKD and appears to optimize management of anemia.
|
Authors | Atinder Panesar, Rajiv Agarwal |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 40
Issue 5
Pg. 924-31
(Nov 2002)
ISSN: 1523-6838 [Electronic] United States |
PMID | 12407636
(Publication Type: Comparative Study, Journal Article)
|
Copyright | Copyright 2002 by the National Kidney Foundation, Inc. |
Chemical References |
- Ferric Compounds
- Recombinant Proteins
- Erythropoietin
- Sucrose
- Iron
- ferric gluconate
|
Topics |
- Administration, Oral
- Aged
- Anemia, Iron-Deficiency
(drug therapy)
- Clinical Pharmacy Information Systems
- Databases as Topic
- Drug Administration Schedule
- Erythropoietin
(administration & dosage, adverse effects, therapeutic use)
- Female
- Ferric Compounds
(administration & dosage, adverse effects, therapeutic use)
- Glomerular Filtration Rate
(drug effects)
- Humans
- Hypotension
(chemically induced)
- Iron
(administration & dosage, adverse effects, therapeutic use)
- Kidney Failure, Chronic
(drug therapy)
- Male
- Medical Records
- Recombinant Proteins
- Retrospective Studies
- Sucrose
(adverse effects, therapeutic use)
- Treatment Outcome
- Veterans
|