Abstract | BACKGROUND: OBJECTIVE: To evaluate the association between DNA polymorphisms at the LRP, LRPAP and alpha2 M genes and early myocardial infarction (MI). METHODS: We genotyped 210 patients with early MI (<55 years) and 200 healthy control participants for three polymorphisms in the LRP, LRPAP and alpha2 M genes. RESULTS: No association was found between these polymorphisms and plasma lipid levels in patients and control participants. Only the LRPAP-intron 1 polymorphism (a 21 bp insertion/deletion) was associated with MI (P = 0.0065; odds ratio = 2.18, 95% confidence intervals = 1.22-3.90). CONCLUSIONS: According to our data, the variation at the LRPAP1 gene could contribute to the risk of developing an early episode of MI.
|
Authors | Pelayo González, Ruth Alvarez, Julián R Reguero, Alberto Batalla, Victoria Alvarez, Arturo Cortina, Gustavo I Cubero, Mónica García-Castro, Eliecer Coto |
Journal | Coronary artery disease
(Coron Artery Dis)
Vol. 13
Issue 5
Pg. 251-4
(Aug 2002)
ISSN: 0954-6928 [Print] England |
PMID | 12394648
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright 2002 Lippincott Williams & Wilkins |
Chemical References |
- LDL-Receptor Related Protein-Associated Protein
- LDL-Receptor Related Proteins
- alpha-Macroglobulins
|
Topics |
- Adult
- Humans
- Introns
(genetics)
- LDL-Receptor Related Protein-Associated Protein
(genetics)
- LDL-Receptor Related Proteins
(genetics)
- Male
- Middle Aged
- Myocardial Infarction
(genetics)
- Polymorphism, Genetic
- alpha-Macroglobulins
(genetics)
|