Abstract | UNLABELLED: The aim of this study was to evaluate the safety and efficacy of intravenous iron saccharate administration in iron-deficient anemic children, under long-term parenteral nutrition, who are unable to tolerate oral iron supplementation or are unresponsive to oral supplementation because of gastrointestinal dysfunction or iron malabsorption. METHODS: Twenty-two infants and children aged 5 months-17 years (median: 38 months) receiving long-term parenteral nutrition and presenting with iron deficiency anemia were included. Total iron to be infused was determined by the formula: total iron (mg) = 0.6 x W (100 - Hb x 100/12) (W: weight, Hb: hemoglobin). Intravenous iron saccharate was given at the hospital. Each patient received a test dose of 25 mg of iron saccharate prior to the initiation of the infusion. Hemoglobin values, reticulocytes count, serum iron, and serum ferritin were determined before iron administration (day 1), as well as 15 and 45 days after iron administration. RESULTS: CONCLUSION: Intravenous iron supplementation with iron saccharate is an efficient procedure, replenishing iron body stores and significantly increasing the hemoglobin concentration. The possible occurrence of allergic reactions emphasizes the need for close medical supervision.
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Authors | L Michaud, D Guimber, K Mention, S Neuville, H Froger, F Gottrand, D Turck |
Journal | Clinical nutrition (Edinburgh, Scotland)
(Clin Nutr)
Vol. 21
Issue 5
Pg. 403-7
(Oct 2002)
ISSN: 0261-5614 [Print] England |
PMID | 12381338
(Publication Type: Journal Article)
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Chemical References |
- Ferric Compounds
- Hemoglobins
- Ferritins
- Iron
- Ferric Oxide, Saccharated
- Glucaric Acid
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Topics |
- Adolescent
- Anemia, Iron-Deficiency
(blood, drug therapy)
- Child
- Child, Preschool
- Erythrocyte Indices
(drug effects)
- Ferric Compounds
(administration & dosage, adverse effects, blood)
- Ferric Oxide, Saccharated
- Ferritins
(blood)
- Glucaric Acid
- Hemoglobins
(drug effects)
- Humans
- Infant
- Infusions, Intravenous
- Iron
(blood)
- Parenteral Nutrition
(adverse effects)
- Reticulocyte Count
- Time Factors
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