Abstract | OBJECTIVE: CASE REPORTS: We applied ointment containing KET (0.25%-1.5%) to the affected area on limbs in 5 patients with complex regional pain syndrome type I (CRPS I) and in 2 patients with type II (CRPS II). One to 2 weeks later, we observed improvement of the report of pain intensity, measured by the visual analog scale, in 4 patients with acute early dystrophic stage of CRPS I. Swelling of the affected limbs subsided as well. No apparent changes were noticed in 1 patient with chronic atrophic stage of CRPS I and in both patients with CRPS II. CONCLUSION: Topical application of KET appears to be beneficial for the patients with acute early dystrophic stage of CRPS I because of either its local anesthetic effect or NMDA receptor antagonist action. Patients with chronic atrophic stage of CRPS I and CRPS II patients do not appear to respond to this treatment.
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Authors | Takahiro Ushida, Toshikazu Tani, Tetsuya Kanbara, Vadim S Zinchuk, Motohiro Kawasaki, Hiroshi Yamamoto |
Journal | Regional anesthesia and pain medicine
(Reg Anesth Pain Med)
2002 Sep-Oct
Vol. 27
Issue 5
Pg. 524-8
ISSN: 1098-7339 [Print] England |
PMID | 12373705
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anesthetics, Dissociative
- Ointments
- Ketamine
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Topics |
- Administration, Topical
- Adult
- Anesthetics, Dissociative
(administration & dosage, therapeutic use)
- Atrophy
- Edema
(drug therapy)
- Hand Injuries
(complications, drug therapy)
- Humans
- Hyperalgesia
(drug therapy)
- Ketamine
(administration & dosage, therapeutic use)
- Male
- Middle Aged
- Ointments
- Pain Measurement
(drug effects)
- Pain Threshold
(drug effects)
- Reflex Sympathetic Dystrophy
(drug therapy, pathology)
- Whiplash Injuries
(complications, drug therapy)
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