HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Frequent polymorphic changes but rare tumor specific mutations of the LATS2 gene on 13q11-12 in esophageal squamous cell carcinoma.

Abstract
We previously reported that loss of heterozygosity on 13q12-13 is related with poor prognosis of esophageal cancer. However, a target tumor-suppressor gene on this region is not yet identified. Recently, LATS2, a new human homologue of the Drosophila tumor suppressor gene (lats/warts) was identified on 13q11-12. We therefore screened esophageal tumor cell lines and tumor tissues to detect tumor specific mutations of the LATS2 gene. Although we found 5 different polymorphisms in this gene (4 kinds of single-base changes and a 6-bp insertion), a tumor specific mutation was identified in only one out of 60 tumor tissues. These results indicated that the LATS2 gene is inactivated in only a small part of esophageal tumors, if any.
AuthorsKanji Ishizaki, Jiro Fujimoto, Hiroshi Kumimoto, Yoshio Nishimoto, Yutaka Shimada, Masayuki Shinoda, Tadashi Yamamoto
JournalInternational journal of oncology (Int J Oncol) Vol. 21 Issue 5 Pg. 1053-7 (Nov 2002) ISSN: 1019-6439 [Print] Greece
PMID12370754 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA, Neoplasm
  • Tumor Suppressor Proteins
  • Protein Kinases
  • LATS2 protein, human
  • Protein Serine-Threonine Kinases
Topics
  • Carcinoma, Squamous Cell (genetics)
  • Chromosomes, Human, Pair 13
  • DNA, Neoplasm (analysis)
  • Esophageal Neoplasms (genetics)
  • Genes, Tumor Suppressor
  • Humans
  • Mutation
  • Polymorphism, Genetic
  • Polymorphism, Single-Stranded Conformational
  • Protein Kinases (genetics)
  • Protein Serine-Threonine Kinases
  • Tumor Cells, Cultured
  • Tumor Suppressor Proteins

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: