Abstract |
We previously reported that loss of heterozygosity on 13q12-13 is related with poor prognosis of esophageal cancer. However, a target tumor-suppressor gene on this region is not yet identified. Recently, LATS2, a new human homologue of the Drosophila tumor suppressor gene ( lats/ warts) was identified on 13q11-12. We therefore screened esophageal tumor cell lines and tumor tissues to detect tumor specific mutations of the LATS2 gene. Although we found 5 different polymorphisms in this gene (4 kinds of single-base changes and a 6-bp insertion), a tumor specific mutation was identified in only one out of 60 tumor tissues. These results indicated that the LATS2 gene is inactivated in only a small part of esophageal tumors, if any.
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Authors | Kanji Ishizaki, Jiro Fujimoto, Hiroshi Kumimoto, Yoshio Nishimoto, Yutaka Shimada, Masayuki Shinoda, Tadashi Yamamoto |
Journal | International journal of oncology
(Int J Oncol)
Vol. 21
Issue 5
Pg. 1053-7
(Nov 2002)
ISSN: 1019-6439 [Print] Greece |
PMID | 12370754
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA, Neoplasm
- Tumor Suppressor Proteins
- Protein Kinases
- LATS2 protein, human
- Protein Serine-Threonine Kinases
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Topics |
- Carcinoma, Squamous Cell
(genetics)
- Chromosomes, Human, Pair 13
- DNA, Neoplasm
(analysis)
- Esophageal Neoplasms
(genetics)
- Genes, Tumor Suppressor
- Humans
- Mutation
- Polymorphism, Genetic
- Polymorphism, Single-Stranded Conformational
- Protein Kinases
(genetics)
- Protein Serine-Threonine Kinases
- Tumor Cells, Cultured
- Tumor Suppressor Proteins
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